Investigating how sex influences genetic factors in depression
The role of sex in genetic association studies of depression
This study is looking at how genes and depression are connected, especially how this connection might be different for men and women, to help create better, personalized treatments for depression based on a person's genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Pilgrim Health Care, INC. NIH-funded |
| Lab location | 1 site (Canton, UNITED STATES) |
| Project ID | NIH-11015034 on NIH RePORTER |
What this research studies
This research explores the complex relationship between genetics and depression, focusing on how these factors differ between males and females. By utilizing large biobanks, including the UK Biobank and the Mass General Brigham Biobank, the study aims to develop new methods for understanding the genetic basis of depression. The goal is to identify sex-specific genetic influences that could lead to more effective treatments for depression. Patients may benefit from insights that could inform personalized treatment strategies based on their genetic makeup and sex.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 18 and older who are experiencing clinical depression.
Not a fit: Patients who do not have depression or are under 18 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for depression based on genetic and sex differences.
How similar studies have performed: Other research has shown promise in understanding genetic influences on depression, but this specific focus on sex differences is relatively novel.
Where this research is happening
Canton, UNITED STATES
- Harvard Pilgrim Health Care, INC. — Canton, United States (Active)
Researchers
- Principal investigator: Lutz, Sharon Marie — Harvard Pilgrim Health Care, INC.
- Study coordinator: Lutz, Sharon Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.