Investigating how sex hormones affect allergic asthma in women
Sex differences in GPER-mediated mechanisms in allergic asthma
This study is looking at how female hormones might affect asthma differently in women compared to men, using lung cells from both to find out how these hormones influence reactions to allergens, with the goal of creating better treatments for women with asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10993234 on NIH RePORTER |
What this research studies
This research explores the differences in allergic asthma between adult women and men, focusing on how female sex hormones, particularly estrogens, influence lung function and responses to allergens. The study will utilize human bronchial epithelial cells from both asthmatic females and males to assess the role of the G protein-coupled estrogen receptor (GPER) in mediating these responses. By examining the signaling pathways activated during allergen exposure, the research aims to uncover sex-specific mechanisms that could lead to better-targeted treatments for asthma in women.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult women with a diagnosis of allergic asthma.
Not a fit: Patients who do not have asthma or who are male may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved asthma treatments specifically tailored for women, addressing the unique ways their bodies respond to allergens.
How similar studies have performed: Previous studies have indicated that sex hormones significantly impact asthma severity and responses, suggesting that this research builds on established findings rather than exploring entirely novel territory.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Silveyra, Patricia — Trustees of Indiana University
- Study coordinator: Silveyra, Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.