Investigating how sex differences related to the X chromosome affect Alzheimer's disease.
Sex Differences in Epigenetic Parent-of-X Origin and Alzheimer's Disease
This study is looking at how being male or female affects Alzheimer's disease, especially focusing on the X chromosome, to find new ways to help both men and women with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10525754 on NIH RePORTER |
What this research studies
This research explores how biological sex influences Alzheimer's disease (AD) by examining the role of the X chromosome in both males and females. Using mouse models and primary neurons, the study employs genetic and epigenetic tools to dissect the mechanisms behind sex-specific vulnerabilities to AD. By understanding these differences, the research aims to identify new pathways that could lead to better treatment strategies for both sexes. The findings may help clarify why women, who have two X chromosomes, experience different outcomes in AD compared to men.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those who are female or have a family history of the condition.
Not a fit: Patients who do not have Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatment options for Alzheimer's disease that take into account sex differences.
How similar studies have performed: While the specific focus on X chromosome mechanisms in Alzheimer's disease is relatively novel, previous research has shown that sex differences play a significant role in various health conditions, indicating potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Dubal, Dena Bou — University of California, San Francisco
- Study coordinator: Dubal, Dena Bou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.