Investigating how sex differences and opioids affect HIV reservoirs
Sex differences in modulating HIV/SIV reservoirs in the context of opioids
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11009283
This study is looking at how being male or female might change the way HIV hides in the body, especially for people who use opioids like morphine, and it aims to find better treatment options for those living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11009283 on ClinicalTrials.gov |
What this research studies
This research explores how sex differences may influence the formation and maintenance of HIV reservoirs in the body, particularly in the context of opioid use. It examines the biological and socio-economic factors that contribute to these differences, using SIV-infected rhesus macaques as a model for HIV infection. The study aims to understand how chronic opioid use, such as morphine, affects the size of viral reservoirs in different parts of the body, including the brain and peripheral tissues. By analyzing these factors, the research seeks to provide insights into more effective treatment strategies for HIV-infected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-infected individuals, particularly those who are opioid users and may experience different disease outcomes based on their sex.
Not a fit: Patients who are not HIV-infected or do not use opioids may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for HIV that take into account sex differences and substance use.
How similar studies have performed: Other research has indicated that understanding sex differences in disease mechanisms can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BYRAREDDY, SIDDAPPA N — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: BYRAREDDY, SIDDAPPA N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus