Investigating how sex differences and opioids affect HIV reservoirs
Official title: Sex differences in modulating HIV/SIV reservoirs in the context of opioids
Funded at University of Nebraska Medical Center · NIH-11009283 · Data updated 2026-11-12
This study is looking at how being male or female might change the way HIV hides in the body, especially for people who use opioids like morphine, and it aims to find better treatment options for those living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $690,750 |
| NIH project number | 1R01DA061678-01 |
| Project ID | NIH-11009283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are HIV-infected individuals, particularly those who are opioid users and may experience different disease outcomes based on their sex.
✕Less likely to help
Patients who are not HIV-infected or do not use opioids may not receive direct benefits from this research.
What this research studies
This research explores how sex differences may influence the formation and maintenance of HIV reservoirs in the body, particularly in the context of opioid use. It examines the biological and socio-economic factors that contribute to these differences, using SIV-infected rhesus macaques as a model for HIV infection. The study aims to understand how chronic opioid use, such as morphine, affects the size of viral reservoirs in different parts of the body, including the brain and peripheral tissues. By analyzing these factors, the research seeks to provide insights into more effective treatment strategies for HIV-infected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for HIV that take into account sex differences and substance use.
How similar studies have gone: Other research has indicated that understanding sex differences in disease mechanisms can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Byrareddy, Siddappa N — University of Nebraska Medical Center
- Study coordinator: Byrareddy, Siddappa N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.