Investigating how sex differences affect lung cancer progression and treatment responses
Development of Mouse and Humanized Models to Study Sex Disparities in Tumor Progression and Treatment of NSCLC
['FUNDING_R21'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-10889246
This study is looking at how lung cancer behaves and responds to treatment differently in men and women, using special models to see how things like hormones and immune responses play a role, which could help improve care for everyone with lung cancer.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10889246 on ClinicalTrials.gov |
What this research studies
This research aims to understand the differences in lung cancer progression and treatment responses between males and females. By developing mouse and humanized models, the study will explore how factors like sex hormones and immune responses contribute to these disparities. The researchers will analyze tumor growth patterns and immune cell activity in both male and female models of non-small cell lung cancer (NSCLC). This approach may reveal critical insights into why men and women respond differently to various cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with non-small cell lung cancer, particularly those interested in understanding how sex may influence their treatment outcomes.
Not a fit: Patients with other types of cancer or those who do not have non-small cell lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, sex-specific treatments for lung cancer.
How similar studies have performed: Previous research has indicated that sex differences can significantly impact cancer progression and treatment responses, suggesting that this approach may yield valuable insights.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LANDRY, JOSEPH WILLIAM — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: LANDRY, JOSEPH WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: American Cancer Society, Cancer Model