Investigating how sex differences affect kidney function and blood pressure regulation
Sex Differences in Renal Sodium Handling
This study is looking at how men and women process salt and manage blood pressure differently, especially how hormones like estradiol play a role, to help find better treatments for kidney health and high blood pressure that fit each person's needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10683265 on NIH RePORTER |
What this research studies
This research explores the differences in how male and female bodies handle sodium and regulate blood pressure, particularly focusing on the role of hormones like estradiol. The study aims to understand the mechanisms behind these differences, especially in the context of kidney health and hypertension. By examining the signaling pathways involved in sodium excretion and blood pressure control, the research seeks to uncover why certain populations, such as postmenopausal women and men, are more prone to kidney-related diseases. Patients may benefit from insights that could lead to more tailored treatments based on sex differences.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hypertension or kidney-related diseases, particularly postmenopausal women and men.
Not a fit: Patients who are premenopausal women or those without hypertension or kidney issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for hypertension and kidney diseases that take into account sex differences.
How similar studies have performed: Other research has shown success in understanding sex differences in cardiovascular health, making this approach promising but still exploring uncharted territory in renal physiology.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Gohar, Eman — Vanderbilt University Medical Center
- Study coordinator: Gohar, Eman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.