Investigating how sex differences affect immune dysfunction and HIV infection.
Sex difference in intestinal immune dysfunction, SHIV infection and reservoir
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10876951
This study is looking at how immune system problems and gut health affect people with HIV/AIDS, especially how these issues differ between men and women, to find better treatment options that take these differences into account.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10876951 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how immune dysfunction and gastrointestinal issues impact individuals living with HIV/AIDS, particularly looking at differences between sexes. It aims to identify immune parameters that vary by sex and are linked to the persistence of the virus and its rebound after treatment interruption. By using a specialized animal model, the study will explore the role of estrogen in HIV persistence and immune activation, which could lead to personalized treatment strategies for those affected by HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV/AIDS, particularly women, who are experiencing immune dysfunction or gastrointestinal issues.
Not a fit: Patients who are not living with HIV/AIDS or those who are not affected by immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized therapies for managing HIV/AIDS, particularly for women who may experience different disease progression.
How similar studies have performed: While there has been some research on sex differences in HIV pathogenesis, this study aims to explore novel aspects of estrogen's role in HIV persistence, making it a potentially groundbreaking investigation.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG, THERESA L — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: CHANG, THERESA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus