Investigating how sex differences affect heart tissue remodeling
Probing sex differences in myocardial fibrosis at multiple length scales using biomaterials
This study is looking at how being male or female affects heart health, specifically focusing on a condition called myocardial fibrosis that can lead to heart failure, and aims to find better treatments that work for both men and women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10687446 on NIH RePORTER |
What this research studies
This research aims to explore how biological sex influences the development of myocardial fibrosis, a condition that can lead to heart failure. By utilizing advanced biomaterial technologies, the study will create models that reflect sex-specific differences in heart tissue remodeling. The goal is to identify tailored therapeutic approaches that can effectively address the unique needs of male and female patients suffering from heart-related conditions. This research addresses a critical gap in understanding female-specific heart failure mechanisms, which have been historically overlooked.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing heart-related issues, particularly women with heart failure or those at risk of developing myocardial fibrosis.
Not a fit: Patients with heart conditions unrelated to myocardial fibrosis or those who do not identify as male or female may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, sex-specific treatments for heart failure and related conditions.
How similar studies have performed: While there has been some research on sex differences in cardiovascular diseases, this approach using biomaterials to create sex-specific models is relatively novel and untested.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Aguado, Brian Alberto — University of California, San Diego
- Study coordinator: Aguado, Brian Alberto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.