Investigating how sex differences affect heart function and arrhythmias in heart failure.
Official title: Sex-dependent cardiac cyclic-AMP signaling and arrhythmias in the failing heart
Funded at University of California at Davis · NIH-11001487 · Data updated 2026-11-12
This study is looking at how heart failure affects men and women differently, especially when it comes to heart rhythms, to help find better treatments that consider whether someone is male or female.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $108,000 |
| NIH project number | 5K99HL171836-02 |
| Project ID | NIH-11001487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with heart failure, particularly those who are experiencing arrhythmias.
✕Less likely to help
Patients without heart failure or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding how heart failure (HF) affects men and women differently, particularly in relation to heart rhythms and function. It explores the mechanisms behind these differences, specifically looking at how certain receptors in the heart respond to signals that regulate heart function. By using advanced techniques to study heart cells and tissues, the research aims to uncover why women may have a lower risk of arrhythmias compared to men. The findings could lead to better-targeted treatments for heart failure based on a patient's sex.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart failure that are tailored to the specific needs of male and female patients.
How similar studies have gone: Previous research has shown promising results in understanding sex differences in heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Caldwell, Jessica — University of California at Davis
- Study coordinator: Caldwell, Jessica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.