Investigating how sex differences affect gastrointestinal fibrosis after radiation exposure
Official title: Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure
Funded at Duke University · NIH-11101325 · Data updated 2026-11-12
This study is looking at how high doses of radiation can cause long-term gut problems, especially in the small intestine and colon, and it wants to see if men and women react differently to this damage, with a focus on finding new ways to help those affected.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 3, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $557,102 |
| NIH project number | 5U01AI183940-02 |
| Project ID | NIH-11101325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to high doses of radiation due to accidents or nuclear events.
✕Less likely to help
Patients who have not been exposed to radiation or do not have gastrointestinal complications related to radiation exposure may not benefit from this research.
What this research studies
This research focuses on understanding how exposure to high doses of radiation can lead to delayed gastrointestinal injuries, particularly fibrosis in the small intestine and colon. The study aims to explore the differences between males and females in their response to radiation, as preliminary findings suggest that females may experience more severe fibrosis. By examining the role of Type I Interferon signaling in this process, the research seeks to uncover potential therapeutic targets for preventing or treating these injuries. Patients may benefit from insights that could lead to new treatments for radiation-induced gastrointestinal complications.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective therapies to prevent or mitigate gastrointestinal damage caused by radiation exposure.
How similar studies have gone: While the specific focus on sex differences in delayed gastrointestinal fibrosis after radiation exposure is novel, related research has shown success in understanding radiation injury mechanisms.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Roper, Jatin — Duke University
- Study coordinator: Roper, Jatin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.