Investigating how sex differences affect colon cancer spread
Official title: Sex specific epigenetic regulation of colon cancer metastasis
Funded at Indiana University Indianapolis · NIH-10698017 · Data updated 2026-11-12
This study is looking at how a gene called KDM5D affects colon cancer differently in men and women, with the goal of finding new treatments that could help improve survival for all patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 6, 2022 |
| Project end | August 31, 2028 |
| Funding year | 2023 |
| Award (this year) | $395,576 |
| NIH project number | 5R01CA262798-02 |
| Project ID | NIH-10698017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include male and female patients diagnosed with metastatic colorectal cancer.
✕Less likely to help
Patients with early-stage colorectal cancer or those without the specific genetic markers being studied may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific gene, KDM5D, in the progression of colon cancer, particularly how it differs between male and female patients. By using both laboratory and animal models, the researchers aim to uncover the mechanisms by which KDM5D influences cancer metastasis. The study seeks to identify potential new therapies that could target this gene to improve outcomes for patients with colon cancer. This research is particularly important as it addresses the observed differences in prognosis between male and female colon cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve survival rates for colon cancer patients, especially males who currently have worse outcomes.
How similar studies have gone: Previous research has shown promise in targeting epigenetic regulators in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Wang, Y. Alan — Indiana University Indianapolis
- Study coordinator: Wang, Y. Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.