Investigating how sex differences affect brain health in people with HIV
Sex differences in the contribution of cerebrovascular injury and immune activation to neurocognitive impairment in HIV infection
This study is looking at how being male or female affects brain health in older adults living with HIV, especially how heart health and inflammation might play a role in memory and thinking problems, so we can find better ways to help both men and women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11030317 on NIH RePORTER |
What this research studies
This research explores how biological sex influences neurocognitive impairment (NCI) in individuals living with HIV, particularly focusing on older adults. It aims to understand the role of cerebrovascular injury and immune activation in cognitive decline, with a specific emphasis on the differences between men and women. The study will assess cardiovascular disease risk factors and inflammation to determine their impact on brain health. By comparing the cognitive health of men and women with HIV, the research seeks to identify tailored therapeutic approaches for each sex.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are living with HIV.
Not a fit: Patients who are not living with HIV or those under the age of 65 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive health interventions specifically designed for women and men living with HIV.
How similar studies have performed: Previous research has indicated significant sex differences in cognitive impairment among individuals with HIV, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Chow, Felicia C. — University of California, San Francisco
- Study coordinator: Chow, Felicia C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.