Investigating how sex differences affect brain development using advanced imaging techniques
Coupling neuroimaging with CLARITY and single cell genomics to dissect sex differences in the developing brain
This study looks at how brain development and neurobehavioral diseases affect boys and girls differently, using mice to see how sex hormones and chromosomes play a role, with the goal of helping us understand these differences in humans better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10788298 on NIH RePORTER |
What this research studies
This research explores how neurobehavioral diseases impact males and females differently, focusing on the role of sex hormones and chromosomes in brain development. Using high-precision MRI imaging, the study examines brain changes in a mouse model with varying sex chromosome configurations at different developmental stages. The findings aim to identify specific brain regions and times when these sex differences emerge, and how they may relate to human brain development and disease. By comparing mouse and human brain development, the research seeks to uncover critical insights into the biological underpinnings of sex differences in neurobehavioral health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in understanding sex differences in brain development and neurobehavioral health, particularly those with a family history of related conditions.
Not a fit: Patients with neurobehavioral diseases that do not exhibit sex differences or those who are not interested in the biological aspects of these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of neurobehavioral diseases that affect males and females differently.
How similar studies have performed: Other research has shown success in using advanced imaging techniques to study brain development, but this specific approach to dissect sex differences is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Arnold, Arthur P — University of California Los Angeles
- Study coordinator: Arnold, Arthur P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.