Investigating how sex differences affect brain cells linked to Autism Spectrum Disorder.
Sex dependent dysregulation of parvalbumin interneurons as a pathway to Autism Spectrum Disorder
['FUNDING_R21'] · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · NIH-11057198
This study is looking at how certain brain cells might be involved in Autism Spectrum Disorder and how they could be affected differently in boys and girls, especially when mothers have specific antibodies during pregnancy, to help find new ways to support those with ASD.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (MANHASSET, UNITED STATES) |
| Trial ID | NIH-11057198 on ClinicalTrials.gov |
What this research studies
This research explores the role of specific brain cells called parvalbumin interneurons in the development of Autism Spectrum Disorder (ASD), focusing on how these cells may be affected differently in males and females. The study examines the impact of maternal antibodies on these brain cells during pregnancy, particularly looking at a protein called Caspr2 that is linked to ASD. By using animal models, the researchers aim to understand the biological mechanisms that may lead to ASD, which could help identify potential interventions or treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include children diagnosed with Autism Spectrum Disorder and their mothers.
Not a fit: Patients who do not have Autism Spectrum Disorder or are not related to affected individuals may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of Autism Spectrum Disorder and pave the way for targeted therapies.
How similar studies have performed: Previous research has indicated that understanding the role of specific brain cells in ASD can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
MANHASSET, UNITED STATES
- FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH — MANHASSET, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRIMBERG, LIOR — FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: BRIMBERG, LIOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.