Investigating how sex differences affect brain cells linked to Autism Spectrum Disorder.
Official title: Sex dependent dysregulation of parvalbumin interneurons as a pathway to Autism Spectrum Disorder
Funded at Feinstein Institute for Medical Research · NIH-11057198 · Data updated 2026-11-12
This study is looking at how certain brain cells might be involved in Autism Spectrum Disorder and how they could be affected differently in boys and girls, especially when mothers have specific antibodies during pregnancy, to help find new ways to support those with ASD.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | September 23, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $251,250 |
| NIH project number | 1R21MH136489-01A1 |
| Project ID | NIH-11057198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include children diagnosed with Autism Spectrum Disorder and their mothers.
✕Less likely to help
Patients who do not have Autism Spectrum Disorder or are not related to affected individuals may not receive any benefit from this research.
What this research studies
This research explores the role of specific brain cells called parvalbumin interneurons in the development of Autism Spectrum Disorder (ASD), focusing on how these cells may be affected differently in males and females. The study examines the impact of maternal antibodies on these brain cells during pregnancy, particularly looking at a protein called Caspr2 that is linked to ASD. By using animal models, the researchers aim to understand the biological mechanisms that may lead to ASD, which could help identify potential interventions or treatments.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of Autism Spectrum Disorder and pave the way for targeted therapies.
How similar studies have gone: Previous research has indicated that understanding the role of specific brain cells in ASD can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Brimberg, Lior — Feinstein Institute for Medical Research
- Study coordinator: Brimberg, Lior
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.