Investigating how sex differences affect blood pressure through a specific olfactory receptor.
Official title: Sex Differences in Blood Pressure and Olfactory Receptor 558 (OLFR558)
Funded at Johns Hopkins University · NIH-11083606 · Data updated 2026-11-12
This study is looking at how a special smell receptor in the kidneys might affect blood pressure differently in men and women, using modified mice to help us learn more about these differences and improve treatments for high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 3, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $616,008 |
| NIH project number | 5R01DK139021-02 |
| Project ID | NIH-11083606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hypertension, particularly those who may have sex-related differences in blood pressure.
✕Less likely to help
Patients who do not have hypertension or those with conditions unrelated to blood pressure regulation may not benefit from this research.
What this research studies
This research explores the differences in blood pressure between males and females, focusing on a specific olfactory receptor known as OLFR558, which is found in the kidneys. The study will utilize genetically modified mice to understand how this receptor influences blood pressure regulation in both sexes. By examining various cell types and hormonal influences, the research aims to uncover the mechanisms behind these sex differences in blood pressure. The findings could lead to better understanding and treatment of hypertension based on sex-specific factors.
Why it matters
Potential benefit: If successful, this research could lead to more effective, sex-specific treatments for hypertension.
How similar studies have gone: Previous research has shown that understanding biological differences between sexes can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Pluznick, Jennifer L — Johns Hopkins University
- Study coordinator: Pluznick, Jennifer L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.