Investigating how sex differences affect blood flow in the brain as we age
Sex differences in cerebral pulsatility and implications for brain health
This study is looking at how changes in blood flow in the brain as we age might affect brain health, especially for older adults with Alzheimer's, and it uses advanced MRI scans to find patterns that could help improve brain blood flow.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10556735 on NIH RePORTER |
What this research studies
This research explores how fluctuations in blood flow within the brain, known as cerebral pulsatility, change with age and differ between men and women. It aims to understand how these changes may contribute to brain health issues, particularly in older adults with conditions like Alzheimer's disease. By utilizing advanced MRI technology, the study will analyze existing brain scans to identify patterns of pulsatility and their implications for cognitive health. The goal is to uncover potential interventions that could improve blood flow regulation in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly women, who are experiencing age-related cognitive changes or have a diagnosis of Alzheimer's disease.
Not a fit: Patients who are younger than 21 or do not have any cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of brain health in older adults, particularly for women who may be at greater risk for cognitive decline.
How similar studies have performed: Previous research has indicated that understanding cerebral pulsatility can provide insights into brain health, suggesting that this approach may yield valuable findings.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Barnes, Jill Nicole — University of Wisconsin-Madison
- Study coordinator: Barnes, Jill Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.