Investigating how sex differences affect Alzheimer's disease through mitochondrial function and metabolic health
Official title: Sex Differences in Alzheimer's disease-Related Pathology: Role of Mitochondrial Function and Metabolic Health
Funded at Massachusetts General Hospital · NIH-11101233 · Data updated 2026-11-12
This study is looking at how metabolic health and energy production in cells might affect Alzheimer's disease, especially in women going through menopause, to find out why they may be at higher risk and how we can help them better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $128,414 |
| NIH project number | 5K01AG081500-03 |
| Project ID | NIH-11101233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women experiencing midlife metabolic changes and those at risk for Alzheimer's disease.
✕Less likely to help
Patients who are not experiencing metabolic dysfunction or who are not at risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding how metabolic health and mitochondrial function contribute to Alzheimer's disease (AD) pathology, particularly in women. The study aims to explore the differences in brain function and disease progression between sexes, especially during the menopausal transition. By examining biomarkers and conducting detailed analyses, the research seeks to uncover the underlying mechanisms that may increase the risk of AD in women. The findings could lead to targeted interventions that address these sex-specific factors.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for Alzheimer's disease, particularly for women.
How similar studies have gone: Other research has shown promising results in understanding sex differences in Alzheimer's disease, indicating that this approach has potential for significant insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Konishi, Kyoko — Massachusetts General Hospital
- Study coordinator: Konishi, Kyoko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.