Investigating how sex differences affect Alzheimer's disease and small vessel disease in the brain.
Population neuroscience of sex differences in the Alzheimer's disease biomarker cascade: The role of cerebral small vessel disease
This study is looking at how being male or female might affect the connection between small blood vessel problems in the brain and Alzheimer's disease in older adults, with the goal of finding better ways to prevent and treat these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11063161 on NIH RePORTER |
What this research studies
This research aims to explore how sex differences influence the relationship between cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). By utilizing advanced imaging techniques and epidemiological methods, the study will assess various biomarkers related to cSVD and AD in older adults. The research will focus on understanding whether men and women exhibit different patterns in these biomarkers, which could lead to tailored approaches in prevention and treatment. Participants may undergo imaging and assessments to help clarify these differences.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults, particularly those over the age of 65, who may be experiencing cognitive decline or have risk factors for Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without any cognitive impairment or risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for Alzheimer's disease that are tailored to sex-specific needs.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in various neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Shaaban, C. Elizabeth — University of Pittsburgh at Pittsburgh
- Study coordinator: Shaaban, C. Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.