Investigating how sex chromosomes affect pancreatic beta-cell function in diabetes
Official title: Sex chromosomes and beta-cell function
Funded at Tulane University of Louisiana · NIH-11132459 · Data updated 2026-11-12
This study is looking at how men and women with Type 2 diabetes might experience the disease differently because of their biology, and it aims to find out how these differences can affect treatment options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | April 9, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $90,071 |
| NIH project number | 1K99DK140067-01A1 |
| Project ID | NIH-11132459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 2 diabetes, particularly those interested in understanding how their sex may influence their condition.
✕Less likely to help
Patients with Type 1 diabetes or those who do not have diabetes may not receive direct benefits from this research.
What this research studies
This research explores the molecular differences in pancreatic beta-cell function related to sex in the context of Type 2 diabetes (T2D). It aims to understand how sex chromosomes and hormones influence the disease's development and treatment response. Using a novel human pancreatic slice culture system, the study employs advanced techniques like single-cell RNA sequencing to identify key regulators of islet function across sexes. This approach seeks to uncover the underlying mechanisms that contribute to sex differences in diabetes pathology.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for Type 2 diabetes based on sex-specific biological differences.
How similar studies have gone: While there is ongoing research into sex differences in diabetes, this specific approach using human pancreatic slices is relatively novel and has not been extensively tested.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Qadir, Mirza Muhammad Fahd — Tulane University of Louisiana
- Study coordinator: Qadir, Mirza Muhammad Fahd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.