Investigating how sex and obesity affect blood pressure responses to low oxygen levels
Sex disparities in hypoxic sympatholysis and impact of obesity
This study is looking at how our bodies manage blood pressure and blood flow when there's not enough oxygen, especially focusing on how this works differently for men and women, and how being overweight might change things; it's for anyone interested in understanding heart health, particularly in conditions like sleep apnea.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10879051 on NIH RePORTER |
What this research studies
This research explores how the body's sympathetic nervous system regulates blood pressure and blood flow during low oxygen conditions, focusing on differences between sexes and the impact of obesity. It aims to understand why women, particularly those who are normal weight, may have a protective response to low oxygen compared to men and obese individuals. By examining these mechanisms, the study seeks to uncover important insights into cardiovascular health, especially in conditions like sleep apnea. The research involves analyzing physiological responses and potential differences in how men and women react to hypoxia, particularly in the context of obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults, particularly premenopausal women, who are normal weight and may be experiencing conditions related to low oxygen levels.
Not a fit: Patients who are not within the age range of 21+ years or those who do not have conditions related to hypoxia or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for hypertension and cardiovascular diseases, particularly in women and obese patients.
How similar studies have performed: Previous research has indicated significant sex differences in cardiovascular responses to hypoxia, suggesting that this study builds on established findings rather than exploring entirely novel territory.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Limberg, Jacqueline K — University of Missouri-Columbia
- Study coordinator: Limberg, Jacqueline K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.