Investigating how sex affects immune interactions in Kawasaki disease
Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitis
This study is looking at how Kawasaki disease affects kids and how the immune system interacts with blood vessels differently in boys and girls, with the goal of finding better treatments for those who don’t respond to regular therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10990212 on NIH RePORTER |
What this research studies
This research focuses on Kawasaki disease, a serious condition that can lead to heart problems in children. It aims to understand how immune cells interact with blood vessels and how these interactions differ between males and females. By studying these differences, the researchers hope to identify better treatments for patients who do not respond to standard therapies. The study will involve both human patients and animal models to explore the underlying mechanisms of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with Kawasaki disease, particularly those who are resistant to standard intravenous immunoglobulin treatment.
Not a fit: Patients with Kawasaki disease who respond well to standard treatments may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Kawasaki disease, reducing the risk of heart complications in affected children.
How similar studies have performed: Previous research has shown success in understanding immune mechanisms in other diseases, suggesting that this approach may yield valuable insights for Kawasaki disease as well.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Arditi, Moshe — Cedars-Sinai Medical Center
- Study coordinator: Arditi, Moshe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.