Investigating how serum amyloid A contributes to amyloid diseases
Structure and Function of Serum Amyloid A in Health and Disease
This study is looking at how a protein called serum amyloid A (SAA) behaves in amyloid diseases, like AA amyloidosis, which can harm your kidneys and liver, to find out how it might help us develop better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11042773 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of serum amyloid A (SAA) in amyloid diseases, particularly AA amyloidosis, which can lead to severe kidney and liver damage. The project aims to explore how SAA interacts with lipids and glycosaminoglycans (GAGs) to influence the misfolding of proteins that cause amyloid deposits. By using advanced biochemical and biophysical techniques, researchers will analyze how these interactions affect amyloid formation, potentially leading to new therapies. Patients with amyloid diseases may benefit from insights gained through this research, which seeks to identify critical mechanisms involved in disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with AA amyloidosis or related amyloid diseases.
Not a fit: Patients with amyloid diseases not related to serum amyloid A may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for patients suffering from amyloid diseases.
How similar studies have performed: Previous research has shown promise in understanding amyloid diseases through similar biochemical approaches, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Gursky, Olga — Boston University Medical Campus
- Study coordinator: Gursky, Olga
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.