Investigating how serum amyloid A connects inflammation and blood clotting
Official title: Serum Amyloid as a Critical mediator between inflammation and thrombosis
Funded at Central Arkansas Veterans Hlthcare Sys · NIH-10106461 · Data updated 2026-11-12
This study is looking at how a protein called serum amyloid A (SAA) connects inflammation to blood clotting, especially in people with heart and blood vessel issues, to find new ways to prevent serious problems like heart attacks and strokes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Arkansas Veterans Hlthcare Sys NIH-funded |
| Lab location | 1 site (North Little Rock, United States) |
| Project start | April 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| NIH project number | 5I01BX004671-03 |
| Project ID | NIH-10106461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with atherosclerotic vascular disease or those experiencing acute or chronic inflammation.
✕Less likely to help
Patients without any history of cardiovascular disease or inflammation-related conditions may not benefit from this research.
What this research studies
This research explores the role of serum amyloid A (SAA) in linking inflammation to thrombosis, particularly in the context of atherosclerotic vascular disease. It aims to understand how elevated levels of SAA during acute and chronic inflammation affect platelet function and contribute to serious cardiovascular events like heart attacks and strokes. By studying these mechanisms, the research seeks to identify potential new treatment strategies that could prevent arterial thrombosis by targeting inflammation. The findings could lead to more effective interventions for patients at risk of cardiovascular complications.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the risk of heart attacks and strokes by targeting inflammation.
How similar studies have gone: Previous research has shown promising results in targeting inflammation to reduce cardiovascular events, suggesting that this approach may be viable.
Where this research is happening
-
Central Arkansas Veterans Hlthcare Sys
North Little Rock, United States Active
Researchers
- Principal investigator: Morris, Andrew J — Central Arkansas Veterans Hlthcare Sys
- Study coordinator: Morris, Andrew J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.