Investigating how SERPINB3 affects cervical cancer treatment resistance
Official title: The role of SERPINB3 in cervical cancer therapeutic resistance
Funded at Washington University · NIH-11181506 · Data updated 2026-11-12
This study is looking at a protein called SERPINB3 that makes cervical cancer cells tougher against radiation treatment, and by figuring out how to reduce its effects, researchers hope to help patients with this type of cancer respond better to radiation therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $559,091 |
| NIH project number | 5R01CA279293-02 |
| Project ID | NIH-11181506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with cervical cancer exhibiting high levels of SERPINB3.
✕Less likely to help
Patients with cervical cancer who do not have high SERPINB3 levels may not benefit from this research.
What this research studies
This research focuses on understanding the role of SERPINB3, a protein linked to resistance against radiation therapy in cervical cancer. By using advanced techniques like CRISPR-Cas9 to knock out SERPINB3, researchers aim to make cervical tumor cells more susceptible to radiation-induced cell death. The study will explore how targeting SERPINB3 can change the tumor environment and enhance the effectiveness of radiation therapy. Patients may benefit from insights into new treatment strategies that could improve outcomes for those with SERPINB3-high tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for cervical cancer patients who currently struggle with therapy resistance.
How similar studies have gone: Previous research has shown promising results in targeting similar biomarkers to enhance cancer treatment effectiveness, suggesting a potential for success in this approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Markovina, Stephanie — Washington University
- Study coordinator: Markovina, Stephanie
Related research
Other NIH-funded projects on the same topics.
-
Community and digital tools to reduce HPV and cervical cancer burden
A nurse or health team will test a community-based, digital strategy to help girls and young women, especially in rural areas, get HPV vaccination and cervical cancer prevention services.
-
Community and digital tools to reduce HPV and cervical cancer in women with HIV
A community- and digital-technology program aims to help girls and young women, including those with HIV, get more HPV vaccination and cervical cancer prevention services.
-
mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
-
Globally useful predictor for cervical cancer treatment response
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
-
HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
-
Hybrid approach to boost cervical cancer screening in Uganda
A tested, community-driven program helps Ugandan women encourage their peers to get free VIA cervical cancer screening.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.