Investigating how SERPINB1 affects T cell function and its role in diseases
Official title: The role of SERPINB1 in T cell function and its contribution to human diseases
Funded at Vanderbilt University Medical Center · NIH-10881953 · Data updated 2026-11-12
This study is looking at a protein called SERPINB1 to see how it affects the immune system, especially in people with primary immunodeficiencies, to better understand how genetic changes can lead to serious infections and autoimmune issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $646,268 |
| NIH project number | 5R01AI168210-02 |
| Project ID | NIH-10881953 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with primary immunodeficiencies or those with unexplained immune dysfunction.
✕Less likely to help
Patients with well-defined immune disorders that do not involve SERPINB1 or primary immunodeficiencies may not benefit from this research.
What this research studies
This research focuses on understanding the role of SERPINB1, a protein that may influence T cell function and immunity. By studying patients with primary immunodeficiencies, the researchers aim to uncover how genetic mutations impact immune responses, particularly in relation to severe infections and autoimmune conditions. The approach combines genetic analysis, biochemistry, and molecular biology to explore the mechanisms behind these immune deficiencies. Patients may undergo genetic testing and immunological assessments to identify potential links between SERPINB1 and their health conditions.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of immune-related diseases, potentially improving treatment options for patients with primary immunodeficiencies.
How similar studies have gone: While the specific role of SERPINB1 in T cell function is novel, similar genetic studies have successfully identified critical immune mechanisms in other conditions.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Martinez Barricarte, Ruben — Vanderbilt University Medical Center
- Study coordinator: Martinez Barricarte, Ruben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.