Investigating how serotonin affects sleep apnea in veterans
Official title: CSRD Research Career Scientist Award Application
Funded at John D Dingell VA Medical Center · NIH-10975947 · Data updated 2026-11-12
This study is looking at how serotonin affects sleep apnea in veterans, especially those with spinal cord injuries, to find new ways to improve treatment and help manage related health problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | John D Dingell VA Medical Center NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | October 1, 2020 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5IK6CX002287-05 |
| Project ID | NIH-10975947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans, particularly those with spinal cord injuries, who are experiencing obstructive sleep apnea.
✕Less likely to help
Patients who do not have obstructive sleep apnea or are not veterans may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of serotonin in obstructive sleep apnea (OSA), particularly in veterans, including those with spinal cord injuries. It examines how serotonin influences key factors such as arousal threshold, chemoreflex sensitivity, and airway patency, which are critical in exacerbating sleep apnea. By studying these mechanisms in animal models, the research aims to identify innovative therapies that could improve treatment compliance and address co-morbidities associated with OSA. The ultimate goal is to enhance the management of sleep apnea and its related health issues in the veteran population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for obstructive sleep apnea, enhancing the quality of life for veterans affected by this condition.
How similar studies have gone: While the specific approach of targeting serotonin in this context may be novel, there is existing research indicating that understanding neuromodulators can lead to advancements in treating sleep apnea.
Where this research is happening
-
John D Dingell VA Medical Center
Detroit, United States Active
Researchers
- Principal investigator: Mateika, Jason H. — John D Dingell VA Medical Center
- Study coordinator: Mateika, Jason H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.