Investigating how serotonin affects sleep apnea in veterans
CSRD Research Career Scientist Award Application
This study is looking at how serotonin affects sleep apnea in veterans, especially those with spinal cord injuries, to find new ways to improve treatment and help manage related health problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | John D Dingell VA Medical Center NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10975947 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of serotonin in obstructive sleep apnea (OSA), particularly in veterans, including those with spinal cord injuries. It examines how serotonin influences key factors such as arousal threshold, chemoreflex sensitivity, and airway patency, which are critical in exacerbating sleep apnea. By studying these mechanisms in animal models, the research aims to identify innovative therapies that could improve treatment compliance and address co-morbidities associated with OSA. The ultimate goal is to enhance the management of sleep apnea and its related health issues in the veteran population.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans, particularly those with spinal cord injuries, who are experiencing obstructive sleep apnea.
Not a fit: Patients who do not have obstructive sleep apnea or are not veterans may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for obstructive sleep apnea, enhancing the quality of life for veterans affected by this condition.
How similar studies have performed: While the specific approach of targeting serotonin in this context may be novel, there is existing research indicating that understanding neuromodulators can lead to advancements in treating sleep apnea.
Where this research is happening
Detroit, United States
- John D Dingell VA Medical Center — Detroit, United States (Active)
Researchers
- Principal investigator: Mateika, Jason H. — John D Dingell VA Medical Center
- Study coordinator: Mateika, Jason H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.