Investigating how serotonin affects cognitive flexibility after cocaine use
Claustrum serotonin and spike-timing plasticity associated with cognitive deficits after cocaine
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF KENTUCKY · NIH-10916179
This study is looking at how a specific brain receptor related to serotonin affects thinking and decision-making in the brain area called the claustrum, especially after using cocaine, to find new ways to help people with substance use disorders improve their cognitive skills and recovery.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-10916179 on ClinicalTrials.gov |
What this research studies
This research explores the role of serotonin 2A receptors in the claustrum, a brain region involved in cognitive flexibility, particularly after cocaine use. It aims to understand how these receptors can influence cognitive deficits associated with substance use disorders. By studying the effects of serotonin on brain signaling and behavior in animal models, the research seeks to identify potential therapeutic targets for improving cognitive function in individuals with substance use disorders. The findings could lead to new treatment strategies that enhance cognitive flexibility and support recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cocaine use and associated cognitive deficits.
Not a fit: Patients who do not have a history of substance use or cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals struggling with substance use disorders by enhancing cognitive flexibility.
How similar studies have performed: Other research has shown promising results using serotonin 2A receptor agonists for improving cognitive function, suggesting this approach may be effective.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDERSON, TANNER — UNIVERSITY OF KENTUCKY
- Study coordinator: ANDERSON, TANNER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.