Investigating how serotonin affects brain circuits related to depression
Official title: Serotonergic modulation of the circuits and cell-types of the lateral habenula
Funded at Boston University Medical Campus · NIH-11092261 · Data updated 2026-11-12
This study is looking at how certain brain cells that release serotonin affect our emotions and behaviors, especially in relation to depression, to help find better treatments for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $565,044 |
| NIH project number | 5R01MH133608-03 |
| Project ID | NIH-11092261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing major depression or related mood disorders.
✕Less likely to help
Patients with depression not responsive to serotonin-based treatments or those with other underlying neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of serotonin-releasing neurons in the brain, particularly how they influence emotional control and behaviors related to depression. By examining the lateral habenula, a brain region linked to evaluating actions and outcomes, the study aims to uncover the mechanisms by which serotonin impacts various cell types and circuits. The researchers will utilize advanced techniques, including single-cell sequencing, to identify specific neuron types and their responses to serotonin, which could lead to improved treatments for depression.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for depression by enhancing our understanding of serotonin's role in brain function.
How similar studies have gone: Previous research has shown promising results in understanding serotonin's role in depression, but this specific approach targeting the lateral habenula is relatively novel.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Wallace, Michael L — Boston University Medical Campus
- Study coordinator: Wallace, Michael L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.