Investigating how selfish genes affect reproduction and genetic conflict
Selfish meiotic drive and the role of RNAi in defending intragenomic conflict
This study is looking into how certain genes can mess up the way traits are passed down during reproduction, which can cause problems like uneven numbers of male and female offspring or even infertility, and it aims to find out how a process called RNA interference might help fix these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11036337 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind selfish meiotic drive systems (SMDs) that disrupt normal genetic inheritance during the formation of gametes. It focuses on understanding how these selfish genes can lead to negative outcomes like skewed sex ratios or sterility. By employing advanced molecular biology techniques and genomic analysis, the study aims to uncover the role of RNA interference (RNAi) in suppressing these selfish genes and resolving genetic conflicts. The findings could provide insights into the evolutionary implications of these genetic phenomena.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or populations affected by genetic disorders related to reproductive issues or skewed sex ratios.
Not a fit: Patients with unrelated genetic conditions or those not experiencing reproductive challenges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing genetic disorders and improving reproductive health.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding genetic conflicts and their implications in other species.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Vedanayagam, Jeffrey — University of Texas San Antonio
- Study coordinator: Vedanayagam, Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.