Investigating how selenium metabolism affects survival in acute myeloid leukemia.
THE ROLE OF SELENOPROTEIN SYNTHESIS PATHWAY IN ACUTE MYELOID LEUKEMIA
This study is looking at how selenium, a nutrient, affects the survival of cells in acute myeloid leukemia (AML), and aims to find new treatment options that could help patients like you by changing how selenium works in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10880271 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of selenium metabolism in acute myeloid leukemia (AML), a common and aggressive form of leukemia in adults. By utilizing advanced bioinformatics and CRISPR screening techniques, the researchers have identified key regulators of selenium metabolism that may influence AML cell survival. The study will involve mouse models and human patient-derived xenografts to explore how manipulating selenium metabolism could lead to new therapeutic strategies for AML. Patients may benefit from insights gained about potential new treatments targeting selenium pathways.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults diagnosed with acute myeloid leukemia.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with acute myeloid leukemia may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve survival rates for patients with acute myeloid leukemia.
How similar studies have performed: While the specific approach of targeting selenium metabolism in AML is novel, related research has shown promise in understanding metabolic pathways in cancer treatment.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Nakada, Daisuke — Baylor College of Medicine
- Study coordinator: Nakada, Daisuke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.