Investigating how seizures affect tau protein spread in Alzheimer's Disease
Seizure-induced enhancement of synaptic signaling regulating tau transmissibility in Alzheimer's Disease
This study is looking at how seizures might make Alzheimer's disease worse by spreading a harmful protein in the brain, and it hopes to find new ways to help people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11080330 on NIH RePORTER |
What this research studies
This research explores the relationship between seizures and the spread of tau protein in Alzheimer's Disease (AD). It aims to understand how neuronal hyperactivity, induced by seizures, can exacerbate AD pathology. Using advanced mouse models and human brain tissue, the study will measure the accumulation of tau and its effects on cognitive decline. By examining the mechanisms of tau transmissibility, the research seeks to identify potential targets for therapeutic intervention in AD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease, particularly those who have experienced seizures.
Not a fit: Patients with Alzheimer's Disease who have not experienced seizures may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that slow down or modify the progression of Alzheimer's Disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of tau in Alzheimer's Disease, but this specific approach using seizure models is relatively novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jensen, Frances E — University of Pennsylvania
- Study coordinator: Jensen, Frances E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.