Investigating how SCN2A affects myelination and brain development in autism.
Role of SCN2A in Myelination and Neural Circuit Development in Autism Spectrum Disorder
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10952653
This study is looking at how a specific gene might affect brain development and hearing in people with autism, aiming to understand why some individuals have trouble processing sounds.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10952653 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the SCN2A gene in myelination and the development of neural circuits in individuals with autism spectrum disorder (ASD). It aims to uncover how abnormalities in auditory processing, which are common in ASD, may be linked to changes in brain connectivity and myelination. The study employs advanced neuroimaging techniques and cellular analysis to explore the interactions between neurons and oligodendrocytes, the cells responsible for myelination. By identifying these mechanisms, the research hopes to shed light on the underlying causes of sensory processing issues in autism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those experiencing auditory processing difficulties.
Not a fit: Patients without a diagnosis of autism spectrum disorder or those not experiencing auditory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for improving auditory processing and overall brain function in individuals with autism.
How similar studies have performed: Previous research has shown promising results in understanding the role of myelination and neural connectivity in autism, indicating that this approach has potential for significant findings.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, JUN HEE — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KIM, JUN HEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder