Investigating how SARS-CoV-2 affects the brain and its role in COVID-19
SARS-CoV-2 tropism in the brain and its relationship to COVID-19 pathogenesis
This study is looking at how the COVID-19 virus affects the brain, using special mice to help us understand its impact on breathing and overall health, which could lead to better treatments for people with COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10890506 on NIH RePORTER |
What this research studies
This research explores the impact of the SARS-CoV-2 virus on the brain, aiming to understand how it contributes to the overall disease process of COVID-19. Researchers will create specialized mouse models that mimic human brain responses to the virus by expressing the SARS-CoV-2 receptor. Through various scientific techniques, they will analyze how the virus interacts with brain cells and its effects on respiratory control. The findings could lead to new insights into COVID-19's mechanisms and potential treatment targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced neurological symptoms related to COVID-19 or are at risk of such complications.
Not a fit: Patients who have not been infected with SARS-CoV-2 or do not exhibit any neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing COVID-19 and its neurological complications.
How similar studies have performed: While the investigation of SARS-CoV-2's effects on the brain is relatively novel, similar research into other viruses affecting the central nervous system has shown promising results.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Yakoub, Abraam M. — Brigham and Women's Hospital
- Study coordinator: Yakoub, Abraam M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.