Investigating how SARS-CoV-2 affects inflammation and blood clotting in COVID-19 patients
Official title: Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
Funded at Ohio State University · NIH-11072965 · Data updated 2026-11-12
This study is looking into how the COVID-19 virus can lead to ongoing health problems, like inflammation and blood clots, in patients, and it aims to find new ways to help improve their recovery and overall health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $3,004,517 |
| NIH project number | 5P01AI175399-02 |
| Project ID | NIH-11072965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced COVID-19 and are suffering from long-term symptoms such as respiratory issues, neurological problems, or blood clotting disorders.
✕Less likely to help
Patients who have not contracted COVID-19 or those without any long-term symptoms related to the virus may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms by which the SARS-CoV-2 virus causes long-term health issues in COVID-19 patients, particularly related to inflammation and blood clotting. The team will explore how the virus alters immune responses in the lungs, brain, and blood circulation, aiming to identify new therapeutic targets. By using advanced animal models and bioinformatics, they will test potential treatments that could reduce inflammation and improve patient outcomes. The research aims to provide insights into the long-term effects of COVID-19 and develop strategies to mitigate these complications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate long-term symptoms and complications associated with COVID-19.
How similar studies have gone: Previous research has shown promising results in understanding the inflammatory responses and complications associated with COVID-19, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Amer, Amal O — Ohio State University
- Study coordinator: Amer, Amal O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.