Investigating how SARS-CoV-2 adapts in humans and affects disease outcomes
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)
This study is looking at how the SARS-CoV-2 virus interacts with our bodies to better understand how it spreads and makes us sick, with the goal of finding new ways to treat COVID-19.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11005770 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between the SARS-CoV-2 virus and the human host by utilizing advanced systems biology techniques. The team will gather extensive biological data and use machine learning to model how the virus replicates and causes disease, aiming to identify potential therapeutic targets. By studying the virus's adaptation from bats to humans, the research seeks to uncover critical networks that influence disease severity and response to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been infected with SARS-CoV-2 or are at high risk for severe COVID-19 disease.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that improve outcomes for patients infected with SARS-CoV-2.
How similar studies have performed: Previous research on host-virus interactions has shown promise in identifying therapeutic targets, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Garcia-Sastre, Adolfo — Icahn School of Medicine at Mount Sinai
- Study coordinator: Garcia-Sastre, Adolfo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.