Investigating how SALTe1 affects aging blood vessels and heart failure in older adults
Official title: The Role of SALTe1 in Vascular Aging and Heart Failure With Preserved Ejection Fraction
Funded at Massachusetts General Hospital · NIH-11048364 · Data updated 2026-11-12
This study is looking at how a specific molecule called SALTe1 affects blood vessel aging and heart health in older adults with heart failure, and it will also explore how exercise might help improve this situation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $708,266 |
| NIH project number | 1R01HL169272-01A1 |
| Project ID | NIH-11048364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing heart failure with preserved ejection fraction.
✕Less likely to help
Patients with heart failure of other types or those who are not of advanced age may not benefit from this research.
What this research studies
This research focuses on understanding the role of SALTe1, a long noncoding RNA, in the aging process of blood vessels and its connection to heart failure with preserved ejection fraction (HFpEF) in older adults. The study aims to explore how SALTe1 influences microvascular function and cellular senescence, which are critical factors in the development of HFpEF. By examining the effects of exercise on SALTe1 levels and its impact on heart health, the research seeks to identify potential therapeutic targets for improving outcomes in patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and quality of life for older adults with heart failure.
How similar studies have gone: Previous research has shown that targeting aging mechanisms can reverse cardiac aging phenotypes, suggesting potential success for this approach.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Li, Haobo — Massachusetts General Hospital
- Study coordinator: Li, Haobo
Related research
Other NIH-funded projects on the same topics.
-
SALTe1 and aging blood vessels in heart failure with preserved ejection fraction
This project will try blocking a molecule called SALTe1 to improve blood vessel health and heart function in older adults with HFpEF.
-
Understanding how aging affects heart health and function
This study is looking at how getting older affects heart health by exploring how the body's natural cleanup process slows down and how this might lead to heart problems, especially in older adults, with hopes of finding new ways to help keep hearts healthy as we age.
-
Developing new therapies for heart failure in older adults
This study is looking at heart failure in older adults, especially those with kidney problems, by using young pigs to better understand the disease and find new ways to deliver treatments that can help improve heart function.
-
How aging affects heart immune cells and heart failure during infections
This study looks at how getting older affects the immune cells in the heart, especially during infections, to help us understand why older adults are more at risk for heart problems and find better treatments for them.
-
Investigating how heart failure and aging affect diaphragm function
This study looks at how heart failure affects the diaphragm's ability to work in older adults and tests possible treatments, like nitrate supplements, to help improve breathing and overall quality of life for those with heart failure.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.