Investigating how SALTe1 affects aging blood vessels and heart failure in older adults
The Role of SALTe1 in Vascular Aging and Heart Failure With Preserved Ejection Fraction
This study is looking at how a specific molecule called SALTe1 affects blood vessel aging and heart health in older adults with heart failure, and it will also explore how exercise might help improve this situation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11048364 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of SALTe1, a long noncoding RNA, in the aging process of blood vessels and its connection to heart failure with preserved ejection fraction (HFpEF) in older adults. The study aims to explore how SALTe1 influences microvascular function and cellular senescence, which are critical factors in the development of HFpEF. By examining the effects of exercise on SALTe1 levels and its impact on heart health, the research seeks to identify potential therapeutic targets for improving outcomes in patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing heart failure with preserved ejection fraction.
Not a fit: Patients with heart failure of other types or those who are not of advanced age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and quality of life for older adults with heart failure.
How similar studies have performed: Previous research has shown that targeting aging mechanisms can reverse cardiac aging phenotypes, suggesting potential success for this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Li, Haobo — Massachusetts General Hospital
- Study coordinator: Li, Haobo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.