Investigating how salt-inducible kinases affect vitamin D and bone health
Official title: The Role of Salt-Inducible Kinases in Vitamin D Regulation and Mineral and Bone Metabolism Disorders
Funded at Massachusetts General Hospital · NIH-10948728 · Data updated 2026-11-12
This study is looking at how certain proteins called salt-inducible kinases (SIKs) affect vitamin D levels and bone health, especially for people with conditions like chronic kidney disease or low parathyroid hormone, to see if blocking these proteins could help improve vitamin D production.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $136,230 |
| NIH project number | 1K01DK140632-01 |
| Project ID | NIH-10948728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from chronic kidney disease mineral and bone disorder (CKD-MBD) or hypoparathyroidism who have low levels of active vitamin D.
✕Less likely to help
Patients who have normal vitamin D levels and do not suffer from bone metabolism disorders may not benefit from this research.
What this research studies
This research explores the role of salt-inducible kinases (SIKs) in the regulation of vitamin D and its impact on bone metabolism disorders. The study focuses on how parathyroid hormone (PTH) signaling influences SIKs and subsequently affects the production of active vitamin D in the kidneys. By utilizing advanced bioinformatics techniques, the research aims to identify specific genomic locations where transcription factors interact to regulate vitamin D synthesis. Ultimately, the project seeks to evaluate the potential of SIK inhibition as a therapeutic approach for conditions like chronic kidney disease mineral and bone disorder (CKD-MBD) and hypoparathyroidism, which are characterized by low levels of active vitamin D.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with vitamin D deficiencies and related bone health issues.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for improving vitamin D metabolism and bone health, indicating that this approach may be viable.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Yoon, Sung-Hee — Massachusetts General Hospital
- Study coordinator: Yoon, Sung-Hee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.