Investigating how S-nitrosylation affects heart signaling during injury and repair
Official title: Role of S-Nitrosylation on Beta-Adrenergic Signaling in Cardiac Injury and Repair
Funded at Duke University · NIH-11002881 · Data updated 2026-11-12
This study is looking at how a special process in the heart, called S-nitrosylation, affects the way heart cells communicate, especially after an injury, to find new ways to help protect the heart and improve its function for people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | December 22, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $724,176 |
| NIH project number | 7R01HL157151-04 |
| Project ID | NIH-11002881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart failure or those who have experienced cardiac injuries.
✕Less likely to help
Patients with non-cardiac related health issues or those without heart conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of S-nitrosylation in the signaling pathways of beta-adrenergic receptors in the heart, particularly during and after cardiac injury. By examining how nitric oxide influences these pathways, the study aims to uncover mechanisms that could protect heart cells from damage and improve heart function. The researchers will utilize advanced genetic models and biochemical techniques to explore the effects of S-nitrosylation on key proteins involved in heart signaling. This could lead to new therapeutic strategies for heart failure and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance heart recovery and function after injury.
How similar studies have gone: Previous research has shown promising results in understanding the role of nitric oxide in cardiac signaling, suggesting that this approach could yield significant insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Koch, Walter J. — Duke University
- Study coordinator: Koch, Walter J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.