Investigating how S-glutathione affects heart muscle protein function
Official title: The role of S-glutathione in regulating cardiac myosin binding protein-C function
Funded at University of Wisconsin-Madison · NIH-11230855 · Data updated 2026-11-12
This study is looking at how a substance called S-glutathione affects a protein important for how your heart muscles work, especially when stress on the heart might cause problems, and it could help us find new ways to treat heart disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $65,207 |
| NIH project number | 7F32HL170509-03 |
| Project ID | NIH-11230855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart disease or those at risk of developing heart-related conditions.
✕Less likely to help
Patients with non-cardiac conditions or those without any heart disease risk factors may not benefit from this research.
What this research studies
This research explores the impact of S-glutathione on cardiac myosin binding protein-C (cMyBP-C), a key protein involved in heart muscle contraction and relaxation. By examining how oxidative stress alters the function of cMyBP-C through modifications, the study aims to understand the mechanisms behind heart cell dysfunction in heart disease. The researchers will isolate the effects of S-glutathionylated cMyBP-C and its interaction with phosphorylation, which is crucial for maintaining heart health. This work could lead to new insights into potential therapeutic strategies for heart disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart disease by targeting the mechanisms that regulate heart muscle function.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that targeting protein modifications can lead to significant advancements in understanding heart disease.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Greenman, Angela — University of Wisconsin-Madison
- Study coordinator: Greenman, Angela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.