Investigating how RNA structures affect gene splicing
Pre-mRNA intronic structures in trans factor binding and alternative splicing
['FUNDING_OTHER'] · CLEMSON UNIVERSITY · NIH-11088888
This study is looking at how RNA changes shape to help create different proteins, which is important for understanding how mistakes in this process can lead to diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEMSON UNIVERSITY (nih funded) |
| Locations | 1 site (CLEMSON, UNITED STATES) |
| Trial ID | NIH-11088888 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the process of alternative splicing, where certain segments of RNA are removed or retained to create different protein variants. By studying the role of RNA structures in the binding of spliceosome factors, the research aims to identify how these structures influence the selection of specific RNA segments for splicing. The methodology involves developing models of RNA secondary structures to pinpoint key motifs that affect splicing decisions, which could lead to insights into the dysregulation of splicing associated with various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders linked to splicing dysregulation.
Not a fit: Patients with conditions unrelated to RNA splicing or those not affected by genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by splicing errors.
How similar studies have performed: Previous research has shown promising results in understanding RNA splicing mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
CLEMSON, UNITED STATES
- CLEMSON UNIVERSITY — CLEMSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LACKEY, LELA LYNN — CLEMSON UNIVERSITY
- Study coordinator: LACKEY, LELA LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.