Investigating how RNA splicing affects heart disease
Official title: Function, composition, and mechanism of RNA splicing factories in cardiomyopathy
Funded at University of Southern California · NIH-11235378 · Data updated 2026-11-12
This study is looking at how a protein called RBM20 affects heart health in people with dilated cardiomyopathy, and it hopes to find new ways to help those with heart issues caused by changes in this protein.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | December 20, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $522,500 |
| NIH project number | 7R01HL160825-03 |
| Project ID | NIH-11235378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with known mutations in the RBM20 gene.
✕Less likely to help
Patients with dilated cardiomyopathy not linked to RBM20 mutations may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, RBM20, in the development of dilated cardiomyopathy, a serious heart condition. The team will explore how mutations in RBM20 disrupt the normal splicing of RNA, which is crucial for heart function. By studying the formation of 'splicing factories' in cells, they aim to uncover the mechanisms that lead to arrhythmias and heart failure. Patients may benefit from insights that could lead to new therapies for heart disease caused by these mutations.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with dilated cardiomyopathy caused by RBM20 mutations.
How similar studies have gone: While the specific approach of studying RBM20 splicing factories is novel, similar research has shown promise in understanding RNA splicing in other diseases.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Murry, Charles E — University of Southern California
- Study coordinator: Murry, Charles E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.