Investigating how RNA splicing affects glioblastoma progression
SON-mediated RNA splicing in glioblastoma
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-10847379
This study is looking at how a specific protein called SON affects the way genes are spliced in glioblastoma, a tough type of brain cancer, to find new ways to help treat patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10847379 on ClinicalTrials.gov |
What this research studies
This research focuses on glioblastoma multiforme (GBM), a highly aggressive brain cancer with limited treatment options. It aims to understand the role of RNA splicing in the development and progression of GBM, particularly how certain proteins influence oncogenic gene expression. By studying the upregulation of the SON protein and its relationship with splicing factors, the research seeks to uncover new therapeutic targets that could lead to improved treatment strategies for patients with GBM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma multiforme who are seeking new treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that significantly improve survival rates for glioblastoma patients.
How similar studies have performed: Other research has shown promising results in targeting RNA splicing in various cancers, suggesting that this approach could be effective in glioblastoma as well.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AHN, ERIN EUN-YOUNG — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: AHN, ERIN EUN-YOUNG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers