Investigating how RNA splice variants and gene fusions contribute to cancer development
The role and mechanism of alternative RNA splice variants and gene fusions as drivers of cancer
This study is looking at how certain genetic changes in brain tumors might help us find better ways to diagnose and treat cancer, so that patients can have more personalized and effective treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10928122 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of alternative RNA splice variants and gene fusions in the development of various cancers, particularly brain tumors. Using genetically engineered mouse models that closely mimic human tumors, the research aims to uncover the mechanisms by which these genetic changes drive cancer. The team will explore specific splice variants and gene fusions to identify potential diagnostic and therapeutic targets, as well as evaluate existing FDA-approved drugs for their effectiveness against these tumors. Patients may benefit from insights that could lead to improved treatment options tailored to their specific cancer profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with brain tumors or other cancers associated with RNA splice variants and gene fusions.
Not a fit: Patients with cancers not driven by RNA splice variants or gene fusions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with specific types of cancer.
How similar studies have performed: Previous research has shown promise in using genetically engineered mouse models to study cancer, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Holland, Eric C. — Fred Hutchinson Cancer Center
- Study coordinator: Holland, Eric C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.