Investigating how RNA modifications respond to stress in the nervous system
Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome
This study is looking at how a specific change in RNA, called m6A, affects the nervous system when we face stress, and it aims to find new ways to understand and treat diseases that harm our movement and senses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11062494 on NIH RePORTER |
What this research studies
This research explores the role of m6A, a common RNA modification, in the nervous system and how it changes in response to environmental stressors. By using advanced techniques, the study aims to identify biomarkers and molecular pathways that are linked to adverse health outcomes, particularly in degenerative diseases affecting motor and sensory neurons. The research will analyze how m6A modifications influence RNA metabolism and contribute to disease mechanisms, potentially leading to new diagnostic tools and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodegenerative diseases or those at risk for such conditions.
Not a fit: Patients with non-neurological conditions or those not affected by environmental stressors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new diagnostics and treatment strategies for neurodegenerative diseases.
How similar studies have performed: Other research in the field of epitranscriptomics has shown promise, indicating that this approach could yield significant insights into RNA regulation and disease.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Weng, Yi-Lan — Methodist Hospital Research Institute
- Study coordinator: Weng, Yi-Lan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.