Investigating how RNA modifications affect SARS-CoV-2
Official title: RNA epigenetic modifications in SARS-CoV-2
Funded at Ohio State University · NIH-11134166 · Data updated 2026-11-12
This study is looking at how certain tiny changes in the virus's genetic material might affect how the SARS-CoV-2 virus behaves and spreads, which could help us find new ways to fight it, especially for people who are dealing with COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $582,618 |
| NIH project number | 1R01AI185617-01A1 |
| Project ID | NIH-11134166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals infected with SARS-CoV-2 or those at high risk of infection.
✕Less likely to help
Patients who are not infected with SARS-CoV-2 or those who have already recovered from the virus may not receive direct benefits from this research.
What this research studies
This research explores the role of specific RNA modifications, particularly N6-methyladenosine (m6A) and pseudouridine (Ψ), in the replication and behavior of the SARS-CoV-2 virus. By utilizing advanced sequencing techniques, the study aims to map these modifications in the virus's RNA and understand how they influence viral replication and the immune response. The research will involve examining human bronchial epithelial cells to see how these modifications affect the virus's ability to replicate and interact with the host's immune system. Patients may benefit from insights gained into how the virus operates, potentially leading to new antiviral strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies targeting RNA modifications to inhibit SARS-CoV-2 replication.
How similar studies have gone: While the specific focus on RNA modifications in SARS-CoV-2 is relatively novel, similar approaches have shown promise in understanding viral mechanisms in other contexts.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Li, Jianrong — Ohio State University
- Study coordinator: Li, Jianrong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.