Investigating how RNA modifications affect prostate cancer and its treatment resistance
Official title: The role and mechanism of RNA m6A modification in the pathogenesis and drug-resistance of prostate cancer
Funded at University of Texas Hlth Science Center · NIH-11062368 · Data updated 2026-11-12
This study is looking at how a specific change in RNA might affect the growth of prostate cancer and how well treatments work, with the hope of finding new ways to help patients manage their disease better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $375,411 |
| NIH project number | 5R01CA279696-03 |
| Project ID | NIH-11062368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced prostate cancer, especially those experiencing treatment resistance.
✕Less likely to help
Patients with early-stage prostate cancer or those not undergoing androgen deprivation therapy may not benefit from this research.
What this research studies
This research explores the role of N6-methyladenosine (m6A) modification in the development and treatment resistance of prostate cancer. By examining how this RNA modification influences cancer cell behavior and response to therapies, the study aims to uncover new insights into the mechanisms behind prostate cancer progression. The research will involve laboratory experiments to analyze m6A levels and their effects on androgen receptor signaling, which is crucial for prostate cancer treatment. Patients may benefit from a better understanding of their disease and potential new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with advanced prostate cancer, particularly those who have developed resistance to current therapies.
How similar studies have gone: Previous research has shown promising results in understanding RNA modifications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Lee, Jihoon — University of Texas Hlth Science Center
- Study coordinator: Lee, Jihoon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.