Investigating how RNA modifications affect obesity and type 2 diabetes
Official title: Epitranscriptomics in human obesity and type 2 diabetes
Funded at Joslin Diabetes Center · NIH-10878203 · Data updated 2026-11-12
This study is looking at how changes in RNA might contribute to obesity and type 2 diabetes, using real patient data to find new ways to help manage these conditions better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,043,780 |
| NIH project number | 1RC2DK139552-01 |
| Project ID | NIH-10878203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with obesity or type 2 diabetes who are interested in contributing to advancements in treatment.
✕Less likely to help
Patients without obesity or type 2 diabetes, or those with other unrelated metabolic disorders, may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA modifications in the development of obesity and type 2 diabetes. By analyzing real patient data, the study aims to uncover new regulatory pathways within metabolic tissues that influence these conditions. The approach involves advanced techniques like ATAC sequencing to explore how changes in RNA and chromatin-associated regulatory RNAs affect gene expression in human tissues. This could lead to identifying new therapeutic targets for better management of these diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively target the underlying causes of obesity and type 2 diabetes.
How similar studies have gone: Other research has shown promising results in understanding metabolic diseases through epigenetic approaches, indicating that this area of investigation has potential for significant breakthroughs.
Where this research is happening
-
Joslin Diabetes Center
Boston, United States Active
Researchers
- Principal investigator: Kulkarni, Rohit N. — Joslin Diabetes Center
- Study coordinator: Kulkarni, Rohit N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.