Investigating how RNA modifications affect lung cancer growth
Official title: The molecular basis of 7SK RNA methylation in non-small cell lung cancer
Funded at University of Florida · NIH-11211101 · Data updated 2026-11-12
This study is looking at how a special change in RNA affects the growth of non-small cell lung cancer, and it hopes to find new ways to treat the disease that could help patients in the future.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $77,328 |
| NIH project number | 3R21CA287107-02S1 |
| Project ID | NIH-11211101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-small cell lung cancer.
✕Less likely to help
Patients with other types of lung cancer or those without a cancer diagnosis may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific RNA modification, known as m6A, in non-small cell lung cancer (NSCLC). Researchers will explore how this modification on 7SK RNA influences cancer cell growth and gene expression. By using advanced techniques like real-time PCR and CRISPR, the study aims to identify the molecular pathways involved and how they contribute to the development of NSCLC. Patients may benefit from insights that could lead to new treatment strategies targeting these molecular mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating non-small cell lung cancer.
How similar studies have gone: Other studies have shown promising results in targeting RNA modifications in cancer, suggesting this approach could be effective.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Xie, Mingyi — University of Florida
- Study coordinator: Xie, Mingyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.