Investigating how RNA modifications affect HIV latency and reactivation
The role of RNA m6A modification in the regulation of HIV latency and reactivation
This study is looking at how a specific change in the HIV virus might help it stay hidden and come back in people who are on treatment, and it aims to find better ways to manage HIV by testing samples from patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10814972 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of N6-methyladenosine (m6A) modification in HIV, particularly how it influences the virus's ability to remain dormant and reactivate in patients undergoing antiretroviral therapy. The team will develop a sensitive assay to measure m6A modifications in HIV transcripts from patient samples, allowing for a better understanding of the virus's behavior in the body. By analyzing these modifications at various stages of HIV latency, the research aims to uncover new insights that could lead to improved treatment strategies for individuals living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have achieved viral suppression.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that effectively target and eliminate latent HIV reservoirs in patients.
How similar studies have performed: Previous research has shown promising results in understanding RNA modifications in other viral infections, suggesting potential for success in this novel approach to HIV latency.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Karn, Jonathan — Case Western Reserve University
- Study coordinator: Karn, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.