Investigating how RNA modifications affect cancer cell behavior and drug resistance
RNA Methylation in Cancer Plasticity and Drug Resistance
This study is looking at how changes in RNA might help bladder cancer cells resist treatment, and it's for patients who want to understand how researchers are working to find better ways to fight this cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10880288 on NIH RePORTER |
What this research studies
This research explores the role of RNA methylation in bladder cancer, focusing on how certain modifications can influence the ability of cancer cells to adapt and resist treatment. By examining two distinct populations of tumor cells, researchers aim to understand the mechanisms behind their reversible transitions and drug resistance. The study employs advanced techniques like methyl-RNA-immunoprecipitation followed by high-throughput sequencing to identify key RNA modifications that may contribute to these processes. Patients may benefit from insights that could lead to more effective treatments targeting drug-resistant cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bladder cancer, particularly those experiencing challenges with treatment resistance.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with bladder cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that overcome drug resistance in bladder cancer.
How similar studies have performed: Previous research has shown promising results in understanding RNA modifications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hodara, Emmanuelle — University of Southern California
- Study coordinator: Hodara, Emmanuelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.